Category:Vanadium

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t is well established that re-engineering of current TB drugs is very much desirable in today TB-drug discovery and development, [1]moreover chances are high that these modified drugs reaches to clinical phase more quickly. However the challenging task for such modifications mainly demands identifying bioactive molecule which can be tailored easily into the known TB drugs and thereby synergies the overall activity of the compound. In this aspect we have recognized coumarin and carbostyril (bio-active and anti-TB agents) candidates for conjugation with TB-drugs. [2]The advantages of such conjugation or hybridizations are: It leads to diverse or dual modes of action, multiple biological activities, modified selectivity profiles and reduced undesired side effects. <ref>Mohammad Asif, Antimicrobial and Anti-tubercular Activity of Quinolone Analogues, Science International

References[edit]

  1. S. Sandhu, Y. Bansal, O. Silakari and G. Bansal, Bioorg. Med. Chem., 2014, 22, 3806–3814
  2. Mohammad Asif, Antimicrobial and Anti-tubercular Activity of Quinolone Analogues, Science International Volume 1 Issue 10, 2013; (b) Kawahara S, Tada A, Nagare H, [Clinical evaluation of new quinolones as antituberculosis drugs]. 1999 Jan; 74 (1):71-5

Pages in category "Vanadium"

The following 5 pages are in this category, out of 5 total.